Delirium future or investigational therapies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Zand, M.D.[2] Pratik Bahekar, MBBS [3]


There are many still unknowns about delirium. Studies are being conducted to understand pathophysiology, more effective ways of prevention, utilization of EEG and CT/MRI scan, etc.

Future or Investigational Therapies

Currently many studies are being conducted such as;

Prevention of Delirium

Studies to Improve Diagnosis and Prevention of Delirium

Studies to Understand Pathophysiology of Delirium


  1. Grover, Sandeep; Dua, Devakshi; Sahoo, Swapnajeet; Chakrabarti, Subho; Avasthi, Ajit (2019). "Effectiveness of melatonin in the management of delirium: A retrospective study". Journal of Mental Health and Human Behaviour. 24 (2): 78. doi:10.4103/jmhhb.jmhhb_56_19. ISSN 0971-8990.
  2. Nishikimi, Mitsuaki; Numaguchi, Atsushi; Takahashi, Kunihiko; Miyagawa, Yasuhiro; Matsui, Kota; Higashi, Michiko; Makishi, Go; Matsui, Shigeyuki; Matsuda, Naoyuki (2018). "Effect of Administration of Ramelteon, a Melatonin Receptor Agonist, on the Duration of Stay in the ICU". Critical Care Medicine. 46 (7): 1099–1105. doi:10.1097/CCM.0000000000003132. ISSN 0090-3493.
  3. Ng, K. T.; Shubash, C. J.; Chong, J. S. (2019). "The effect of dexmedetomidine on delirium and agitation in patients in intensive care: systematic review and meta-analysis with trial sequential analysis". Anaesthesia. 74 (3): 380–392. doi:10.1111/anae.14472. ISSN 0003-2409.
  4. Soh, Sarah; Shim, Jae-Kwang; Song, Jong-Wook; Choi, Nakcheoul; Kwak, Young-Lan (2019). "Preoperative transcranial Doppler and cerebral oximetry as predictors of delirium following valvular heart surgery: a case–control study". Journal of Clinical Monitoring and Computing. 34 (4): 715–723. doi:10.1007/s10877-019-00385-x. ISSN 1387-1307.
  5. Nitchingham, Anita; Kumar, Varun; Shenkin, Susan; Ferguson, Karen J.; Caplan, Gideon A. (2018). "A systematic review of neuroimaging in delirium: predictors, correlates and consequences". International Journal of Geriatric Psychiatry. 33 (11): 1458–1478. doi:10.1002/gps.4724. ISSN 0885-6230.
  6. Kimchi, Eyal Y.; Neelagiri, Anudeepthi; Whitt, Wade; Sagi, Avinash Rao; Ryan, Sophia L.; Gadbois, Greta; Groothuysen, Daniël; Westover, M. Brandon (2019). "Clinical EEG slowing correlates with delirium severity and predicts poor clinical outcomes". Neurology. 93 (13): e1260–e1271. doi:10.1212/WNL.0000000000008164. ISSN 0028-3878.
  7. Wang, Ping; Velagapudi, Ravikanth; Kong, Cuicui; Rodriguiz, Ramona M.; Wetsel, William C.; Yang, Ting; Berger, Miles; Gelbard, Harris A.; Colton, Carol A.; Terrando, Niccolò (2020). "Neurovascular and immune mechanisms that regulate postoperative delirium superimposed on dementia". Alzheimer's & Dementia. 16 (5): 734–749. doi:10.1002/alz.12064. ISSN 1552-5260.

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