Nabumetone overdose
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overdose topics
Manifestations
Treatment
Long term effects
Manifestations
Symptoms following acute NSAIDs overdoses are usually limited to lethargy, drowsiness,
nausea, vomiting, and epigastric pain, which are generally reversible with supportive care.
Gastrointestinal bleeding can occur. Hypertension, acute renal failure, respiratory depression, and
coma may occur, but are rare. Anaphylactoid reactions have been reported with therapeutic ingestion
of NSAIDs, and may occur following an overdose. Return to top
Treatment
Patients should be managed by symptomatic and supportive care following a NSAIDs
overdose. There are no specific antidotes. Emesis and/or activated charcoal (60 to 100 grams in adults,
1 to 2 g/kg in children), and/or osmotic cathartic may be indicated in patients seen within 4 hours of
ingestion with symptoms or following a large overdose (5 to 10 times the usual dose). Forced diuresis,
alkalinization of urine, hemodialysis, or hemoperfusion may not be useful due to high protein binding. Return to top
Long term effects
There have been overdoses of up to 25 grams of RELAFEN reported with no long-term
sequelae following standard emergency treatment (i.e., activated charcoal, gastric lavage, IV
H2-blockers, etc.). Return to top
Adapted from the FDA Package Insert.