Editor-In-Chief: C. Michael Gibson, M.S., M.D. 
The largest known ingestion was 13.5 grams in a patient who took sertraline hydrochloride alone and subsequently recovered. However, another patient who took 2.5 grams of sertraline hydrochloride alone experienced a fatal outcome.
Other important adverse events reported with sertraline hydrochloride overdose (single or multiple drugs) include bradycardia, bundle branch block, coma, convulsions, delirium, hallucinations, hypertension, hypotension, manic reaction, pancreatitis, QT-interval prolongation, serotonin syndrome, stupor and syncope.
Treatment should consist of those general measures employed in the
management of overdosage with any antidepressant.
Ensure an adequate airway, oxygenation and ventilation. Monitor cardiac rhythm and vital
signs. General supportive and symptomatic measures are also recommended. Induction of emesis
is not recommended. Gastric lavage with a large-bore orogastric tube with appropriate airway
protection, if needed, may be indicated if performed soon after ingestion, or in symptomatic
Activated charcoal should be administered. Due to large volume of distribution of this drug,
forced diuresis, dialysis, hemoperfusion and exchange transfusion are unlikely to be of benefit.
No specific antidotes for sertraline are known.
In managing overdosage, consider the possibility of multiple drug involvement. The physician
should consider contacting a poison control center on the treatment of any overdose. Telephone
numbers for certified poison control centers are listed in the Physicians’ Desk Reference®
Adapted from the FDA Package Insert.